To summarize our previous article about Bio-FETs, Biologically active field-effect transistors (BioFETs) are miniaturized silicon-based electrochemical biosensors that can detect biomolecular interactions occurring at the gates of MOSFETs. Compared to the conventional optical and mass spectrometry detection methods, BioFETs provide fast, label-free, high sensitivity and direct electronic signal readout. FET-based biosensors have the potential for developing high-throughput label-free microarrays for applications in clinical diagnostics, drug discovery, food monitoring, and bioterrorist security inspection. The following steps are involved in the fabrication of a Bio-FET system: Finding a substrate suitable for serving as a FET site, and forming a FET on the substrate. Exposing an active site of the FET from the substrate. Providing a sensing film layer on the active site of FET. Providing a receptor on the sensing film layer in order to be used for ion detection Removing a semic
Most people tend to perceive electronics and its applications primarily limited to multimedia entertainment, security systems, drones, autonomous systems and other component-based devices. However, these overlook the extensive applications electronics has to biology and biological systems. The intermingling of biology and electronics is so expansive today that there are subspecialties that range from biomolecular (i.e Bioelectronics) to the gross integration of robots, biology and electronics (Biomechatronics). One such application we intend to briefly touch upon today is Bio-FET. A field-effect-transistor-based biosensor, also referred to as Bio-FET are field-effect transistors that are gated by changes within the surface potential induced by the binding of molecules. When charged biomolecules bind to the FET gate made from dielectric material they will change the charge distribution of the underlying semiconductor material leading to a change in conductance of the FET channel. A Bi